If you’re immunocompromised or taking prescription medications, you should talk with your doctor about any potential side effects. Children should also be seen by a doctor before beginning the use of CBD. Use CBD to supplement conventional care, not necessarily replace it. The risks of replacing any proven conventional treatment with an alternative unproven therapy, such as CBD, have not been well-studied. Many patients are able to tolerate the reactions between Cannabis and the pharmaceutical medications they take.
The keywords searched were "cannabinoids", "cannabidiol" and "side effects". Also, chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans. Based on recent advances in cannabinoid administration in humans, controlled CBD may be safe in humans and animals. However, further studies are needed to clarify these reported in vitro and in vivo side effects.
When combined with Cannabis a potentiation of effects related to drowsiness and sedation can occur. cytochrome P450, a group of liver enzymes that are responsible for metabolizing nearly 60% of all medications, both prescribed and OTC. This is particularly true of drugs that have similar health effects as CBD, such as antiepileptic drugs, NSAIDs, and sedatives. No research shows that CBD oil taken on its own can thin the blood. A previously cited 2017 study titled, “A single dose hemp oil for sale of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study” published in the journal JCI Insight, supports CBD’s ability to lower blood pressure.
Instead of using pharmaceutical pain-relievers, which may have severe side effects, aged people are opting for natural alternatives such as CBD oil to manage their discomforts. With the number of senior citizens growing, it’s not surprising that CBD oil products are becoming increasingly popular as a natural remedy for age-related health conditions such as pain. When these liver enzymes increase, it is usually indicative of ongoing stress on the organ and potential liver damage.
The research in this area is still not conclusive, but these preliminary results suggest that caution would be advised when taking these two medications. Our body metabolises 90% of the drugs that we consume with what is called the cytochrome P-450 enzyme system. This system breaks down the substances we consume and turns them into simpler substances that our body can use. One known effect of taking CBD in large doses is that it can inhibit the effectiveness of this system.